promethazine hydrochloride (phenergan) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Promethazine is a phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. Promethazine HCl Oral Solution is useful for: perennial and seasonal allergic rhinitis. Allergic conjunctivitis due to inhalant allergens and foods. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Preoperative, postoperative, or obstetric sedation. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. Therapy adjunctive to meperidine or other analgesics for control of post-operative pain. Active and prophylactic treatment of motion sickness. Antiemetic therapy in postoperative patients.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral, Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0473 - $24.1667

Australia

$1.8282
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( meperidine (demerol), promethazine hydrochloride (phenergan) )
|
( phenylephrine (Prefrin), promethazine hydrochloride (phenergan) - other names: pherazine vc, promethazine vc plain, prometh vc plain )
|
( phenylephrine (Prefrin), promethazine hydrochloride (phenergan), codeine (Phenergan) - other names: pherazine vc w/ codeine, promethazine vc w/ codeine, prometh hydrochloride,phenylephrine hydrochloride w/codeine phosphate, prometh vc w/ codeine )
|
( promethazine hydrochloride (phenergan), codeine (Phenergan) - other names: pherazine w/ codeine, promethazine with codeine )
|
( dextromethorphan (delsym), promethazine hydrochloride (phenergan) - other names: pherazine dm, promethazine dm, promethazine w/ dextromethorphan )

Alternative names

10-(2-dimethylaminopropyl)phenothiazine | 10-[2-(dimethylamino)propyl]phenothiazine | (2-dimethylamino-2-methyl)ethyl-n-dibenzoparathiazine | avomine | diphergan | mymethazine fortis | n-(2'-dimethylamino-2'-methyl)ethylphenothiazine | n,n,alpha-trimethyl-10h-phenothiazine-10-ethanamine | n,n,α-trimethyl-10h-phenothiazine-10-ethanamine | phenergan | phenergan nightime | phenhalal | phensedyl | proazamine | prometazin | prometazina | promethacon | promethazine | promethazine hcl | promethazine hydrochloride | promethazine hydrochloride plain | promethazine plain | promethazine teoclate | promethazinum | promethegan | prometh fortis | prometh plain | protazine | q-mazine | remsed | sarantihist | zipan-25 | zipan-50

Organizations (86)

Research & Development (38)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (49)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (38)

Approved Indications (5)


 

Conjunctivitis, Allergic (approved 2010)

Motion Sickness (approved 2010)

Postoperative Nausea and Vomiting (approved 2010)

Rhinitis, Allergic, Perennial (approved 2010)

Rhinitis, Allergic, Seasonal (approved 2010)

Experimental Indications - Clinical Trial Phases 1-4 (34)


 

Aggression (Phase 4)

Anxiety (Phase 4)

Anxiety Disorders (Phase 3)

Conscious Sedation (Phase 3)

Crohn Disease (Phase 2)

Dementia (Phase 3)

Depression (Phase 3)

Diabetes Mellitus (Phase 2)

Epilepsy (Phase 2)

Healthy Volunteers (Phase 1)

Hepatitis C, Chronic (Phase 4)

Hyperemesis Gravidarum (Phase 3)

Hypersensitivity (Phase 1)

Labor Pain (Phase 2/Phase 3)

Liver Diseases (Phase 4)

Liver Failure (Phase 4)

Low Back Pain (Phase 4)

Migraine Disorders (Phase 2)

Migraine with Aura (Phase 3)

Migraine without Aura (Phase 3)

Nausea (Phase 4)

Pain (Phase 3)

Postoperative Complications (Phase 4)

Postoperative Nausea and Vomiting (Phase 4)

Pregnancy Complications (Phase 4)

Pruritus (Phase 4)

Psychiatry (Phase 4)

Psychophysiologic Disorders (Phase 3)

Psychotic Disorders (Phase 3)

Schizophrenia (Phase 3)

Snake Bites (Phase 4)

Vertigo (Phase 3)

Vestibular Diseases (Phase 4)

Vomiting (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 32
  • # of Trial Organizations: 38

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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