Active Ingredient History
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. It is used for symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Anxiety (Phase 4)
Anxiety Disorders (Phase 4)
Child Behavior (Phase 3)
Chronic Urticaria (Phase 4)
Conscious Sedation (Phase 4)
Dementia (Phase 3)
Dental Caries (Phase 4)
Depression (Phase 3)
Feeding and Eating Disorders (Phase 4)
Healthy Volunteers (Phase 4)
Hydroxyzine (Phase 4)
Meperidine (Phase 4)
Midazolam (Phase 4)
Myeloproliferative Disorders (Phase 3)
Nausea (Phase 4)
Pain (Phase 4)
Pruritus (Phase 4)
Psychological Distress (Phase 4)
Psychophysiologic Disorders (Phase 3)
Schizophrenia (Phase 3)
Sleep Disorders, Intrinsic (Phase 4)
Smoking Cessation (Phase 4)
Vomiting (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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