Active Ingredient History

  • Now
Metirosine is an antihypertensive drug. Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA). Because the first step is also the rate-limiting step, blockade of tyrosine hydroxylase activity results in decreased endogenous levels of catecholamines and their synthesis. This consequently, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body,usually measured as decreased urinary excretion of catecholamines and their metabolites. One main end result of the catecholamine depletion is a decrease in blood presure. Metirosine is used for the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma.   NCATS

  • SMILES: C[C@](N)(CC1=CC=C(O)C=C1)C(O)=O
  • Mol. Mass: 195.2151
  • ALogP: 0.74
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$169.9103 - $251.2563
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

(-)-alpha-methyl-l-tyrosine | alpha-methyl-paratyrosine | demser | l-588357-0 | l-metyrosine | methyltyrosine | metirosin | metirosina | metirosine | métirosine | metirosinum | metyrosine | mk-781 | (s)-alpha-methyltyrosine | α-methyl-l-p-tyrosine | (–)-α-methyl-l-tyrosine | α-methyl-para-tyrosine | α-methyl-p-tyrosine | α-mpt


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