Active Ingredient History

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Tirofiban is a non-peptide antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor. Tirofiban is a reversible, competitive inhibitor of GP IIb/IIIa receptors, exerting its effects via the prevention of the binding of fibrinogen and other ligands, resulting in the inhibition of the last common step of thrombi formation. Tirofiban was discovered by Merck, USA, and was approved by the FDA in 1998 under the trade name AGGRASTAT. AGGRASTAT, in combination with heparin, is indicated for the treatment of acute coronary syndrome, including patients who are to be managed medically and those undergoing percutaneous transluminal coronary angioplasty or atherectomy. AGGRASTAT reduces the risk of ischaemic complications in patients with unstable angina/non-Q-wave myocardial infarction and high-risk patients undergoing revascularisation when used against a background of heparin and aspirin. Furthermore, the drug has an acceptable tolerability profile. Therefore, intravenous tirofiban is likely to be used as an adjunct to heparin and aspirin in patients with acute coronary syndromes including high-risk patients undergoing revascularisation.   NCATS

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Drug Pricing (per unit)

United States

$55.9200 - $91.9600


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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

(2s)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid | aggrastat | aggrestat | agrastat | cahill may roberts brand of tirofiban hydrochloride monohydrate | l 700462 | l-700462 | l-700,462 | merck brand of tirofiban hydrochloride monohydrate | merck frosst brand of tirofiban hydrochloride monohydrate | merck sharp & dohme brand of tirofiban hydrochloride monohydrate | mk 383 | mk-383 | msd brand of tirofiban hydrochloride monohydrate | n-(butylsulfonyl)-o-(4-(4-piperidyl)butyl)-l-tyrosine | tirofiban | tirofiban hcl | tirofiban hydrochloride | tirofiban hydrochloride monohydrate | tirofibanum


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