Active Ingredient History

  • Now
Trimipramine is a tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. It was sold under brand name surmontil for the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. In studies with neurotic outpatients, the drug appeared to be equivalent to amitriptyline in the less-depressed patients but somewhat less effective than amitriptyline in the more severely depressed patients. In hospitalized depressed patients, trimipramine and imipramine were equally effective in relieving depression. Trimipramine has been reported to differ from other typical tricyclic antidepressant drugs in several aspects, for instance it does not inhibit neuronal transmitter uptake and does not cause down-regulation of beta-adrenoceptors. Moreover, it may possess antipsychotic activity in schizophrenic patients. In addition, was found that it did not antagonize the inhibitory effect of noradrenaline and 5-hydroxytryptamine on the release of transmitter, mediated by presynaptic auto receptors. In radioligand binding studies, trimipramine showed fairly high affinities for some dopamine (DA), noradrenaline and 5-hydroxytryptamine (5-HT) receptor subtypes (5-HT2 receptors = alpha 1A/B-adrenoceptors greater than or equal to D2 receptors), intermediate affinities for D1 receptors, alpha 2B-adrenoceptors and 5-HT1C receptors but only low affinities for alpha 2A-adrenoceptors, 5-HT1A, 5-HT1D and 5-HT3 receptors. It may thus be classified as an atypical neuroleptic drug.   NCATS

  • SMILES: CC(CN(C)C)CN1c2ccccc2CCc3ccccc13
  • Mol. Mass: 294.44
  • ALogP: 4.12
  • ChEMBL Molecules:
More Chemistry

Drug Pricing (per unit)

United States

$2.4413 - $5.6340
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

10,11-dihydro-n,n,beta-trimethyl-5h-dibenz[b,f]azepine-5-propanamine | 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5h-dibenz[b,f]azepine | 5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5h-dibenzo[b,f]azepine | 7162 rp | beta-methylimipramine | il-6001 | rhotrimine | rp-7162 | sapilent | surmontil | trimeprimina | trimeprimine | trimeproprimine | trimipramina | trimipramine | trimipramine maleate | trimipramine maleate salt | trimipramine mesylate | trimipramine monohydrochloride | trimipraminum


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue