Active Ingredient History

  • Now
IODOHIPPURIC ACID I-131 (ortho-Iodohippuric Acid I-131, [I-123]-OIH) is an iodine-containing compound used in pyelography as a radiopaque medium. Iodine-123 labelled ortho-Iodohippuric acid was used in the early 1970's as a kidney imaging agent or tracer that "lights-up" inside your body when scanned, but over the years its use has declined. [I-123]-OIH is primarily extracted by the renal tubules and has excellent pharmacokinetic properties, with a clearance only slightly less than that of p-aminohippuran, but its use has been compromised by the suboptimal imaging characteristics of the 364-keV photon of 131I and the delivery of relatively high radiation doses to kidneys and thyroid in patients with impaired renal function   NCATS

  • SMILES: OC(=O)CNC(=O)C1=CC=CC=C1[131I]
  • Mol. Mass: 309.0708
  • ALogP: 1.11
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Parenteral
  • Pro Drug: No
hippuran | hippuran-131 | hippuran (131i) | hippuran i131 | hipputope | iodohippurate sodium i131 | iodohippurate sodium i 131 | iodohippurate sodium i-131 | sodium iodohippurate (131i) | sodium iodohippurate (131i) injection


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