Active Ingredient History

  • Now
Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol and trihex has been in clinical usage for decades.It is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism. Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement. Trihexyphenidyl is indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0565 - $0.3175
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

agitane | apo-trihex | artane | bentex | benzhexol | benzhexol hcl | benzhexol hydrochloride | broflex | (rs)-1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol | tremin | trihexifenidilo | trihexyphenidyl | trihexyphénidyle | trihexyphenidyl hcl | trihexyphenidyl hydrochloride | trihexyphenidylum


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