Active Ingredient History
Fenoldopam (marketed under the brand name Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. Fenoldopam Mesylate Injection, USP is indicated for the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. NCATS
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Hypertension (approved 1997)
Acute Kidney Injury (Phase 4)
Arteries (Phase 3)
Cardiac Surgical Procedures (Phase 2)
Cardiopulmonary Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
General Surgery (Phase 2)
Heart Diseases (Phase 4)
Hypertension (Phase 1)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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