Active Ingredient History

NOW
  • Now
Trimethoprim (TMP) is an antibiotic is used for the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus. Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests. Trimethoprim is rapidly absorbed following oral administration. It exists in the blood as unbound, protein-bound, and metabolized forms. Ten to twenty percent of trimethoprim is metabolized, primarily in the liver; the remainder is excreted unchanged in the urine. The principal metabolites of trimethoprim are the 1- and 3-oxides and the 3'- and 4'-hydroxy derivatives. The free form is considered to be the therapeutically active form. Approximately 44% of trimethoprim is bound to plasma proteins. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. This binding is very much stronger for the bacterial enzyme than for the corresponding mammalian enzyme   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.1696 - $6.7823

Australia

$0.1883 - $0.5959
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( sulfamethoxazole (gantanol), trimethoprim - other names: bactrim, bactrim pediatric, cotrim, cotrim d.s, septra, septra ds, septra grape, sulfamethoprim, sulfamethoprim-ds, sulfamethoxazole and trimethoprim double strength, sulfamethoxazole and trimethoprim single strength, sulfatrim, sulfatrim-ds, sulfatrim pediatric, sulfatrim-ss, trimeth/sulfa )
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2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine | 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine | aminobenzene | aminophen | anilin | anilina | aniline | aniline, (13)c-labeled cpd | aniline, (14)c-labeled cpd | aniline, 15n-labeled cpd | aniline, 2-(13)c-labeled cpd | aniline, 3-(13)c-labeled cpd | aniline, 3h-labeled cpd | aniline, 4-(13)c-labeled cpd | aniline aluminium salt | aniline, conjugate acid | aniline dihydrofluoride | aniline diphosphate (1:1) | aniline diphosphate (3:1) | aniline diphosphate (4:1) | aniline hydrobromide | aniline hydrochloride | aniline hydrochloride-(14)c-labeled cpd | aniline hydrochloride-(15)n-labeled cpd | aniline hydrofluoride | aniline hydrogen iodide | aniline, ion(1+) | aniline, magnesium (1:1) salt | aniline, monolithium salt | aniline monosulfate | aniline nitrate | aniline oil | aniline perchlorate | aniline phosphate (1:1) | aniline phosphate (1:2) | aniline phosphate (2:1) | aniline phosphonate (1:1) | aniline, sodium salt | aniline sulfate | aniline sulfate (2:1) | aniline sulfate (2:1), (14)c-labeled cpd | anilinum | benzenamine | benzeneamine | bw-5672 | bw-56-72 | bw-72u | fentanyl impurity f | huile d'aniline | ipral | kyanol | ledatrim | monotrim | phenylamine | polytrim | primsol | proloprim | proloprin | septra | syraprim | tcmdc-125538 | tiempe | trimethioprim | trimethoprim | triméthoprime | trimethoprim hcl | trimethoprim hydrochloride | trimethoprim specified impurity k | trimethoprim sulfate | trimethoprimum | trimetoprim | trimetoprima | trimogal | trimopan | trimpex | trimpex 200 | triprimix 200

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