Active Ingredient History

  • Now
Pramoxine (also known as pramocaine or pramoxine HCI) is a topical anesthetic and antipruritic. Pramoxine is used to temporarily relieve itching and pain caused by minor skin irritation such as minor burns/cuts/scrapes, sunburn, eczema, insect bites, cold sores, or rashes from poison ivy, poison oak, or poison sumac. Some products containing pramoxine are also used to temporarily relieve the itching and discomfort from hemorrhoids and certain other problems of the genital/anal area (such as anal fissures, itching around the vagina/rectum). Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation. Pramoxine reversibly binds and inhibits voltage gated sodium channels on neurons decreasing sodium permeability into the cell. This stabilizes the membrane and prevents ionic fluctuations needed for depolarization stopping any action potential propagation.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0704 - $0.0886
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( urea, pramocaine - other names: epifoam, proctofoam hc )
4-(3-(4-butoxyphenoxy)propyl)morpholine | 4-(3-(p-butoxyphenoxy)propyl)morpholine | abbott brand of pramoxine hydrochloride | ascher brand of pramoxine hydrochloride | balsabit | ferndale brand of pramoxine hydrochloride | fleet brand of pramoxine hydrochloride | fleet pain relief | genderm brand of pramoxine hydrochloride | isdin brand of pramoxine hydrochloride | itch-x | medicis brand of pramoxine hydrochloride | pramegel | pramocain | pramocaine | pramocaine hydrochloride | pramox | pramoxin | pramoxine | pramoxine hcl | pramoxine hydrochloride | prax | proctofoam | ross brand of pramoxine hydrochloride | schwarz brand of pramoxine hydrochloride | seid brand of pramoxine hydrochloride | tronolane | tronothane


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