ornithine Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Ornithine is also a precursor of citrulline and arginine. Arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of arginine in tissues throughout the body. As de novo synthesis of arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to arginine).   NCATS

Chemistry

  • SMILES: NCCC[C@H](N)C(O)=O
  • InChIKey: AHLPHDHHMVZTML-BYPYZUCNSA-N
  • Mol. Mass: 132.161
  • ALogP: -0.86
  • ChEMBL Molecule:
    ornithine  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

levo-ornithine | l-ornithine | ocr-002 | ornithine | ornithine phenylacetate | (s)-2,5-diaminopentanoate | (s)-2,5-diaminopentanoic acid | (s)-2,5-diaminovaleric acid | (s)-alpha,delta-diaminovaleric acid | (s)-ornithine | (s)-α,δ-diaminovaleric acid

Organizations (9)

Research & Development (9)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (8)

Approved Indications (1)


 

Nutrition Disorders

Experimental Indications - Clinical Trial Phases 1-4 (7)


 

Fibrosis (Phase 2/Phase 3)

Hepatic Encephalopathy (Phase 3)

Intestinal Neoplasms (Phase 2/Phase 3)

Liver Cirrhosis (Phase 2)

Liver Diseases (Phase 2)

Liver Failure, Acute (Phase 2)

Periodontitis (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 9
  • # of Trial Organizations: 9

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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