Active Ingredient History

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Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine. Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.   NCATS

More Chemistry

Combination drugs

( norepinephrine (levophed), procaine merethoxylline, propoxycaine )
( procaine merethoxylline, propoxycaine, levonordefrin (Neo-Cobefrine) )
2-diethylaminoethyl p-aminobenzoate | 4-aminobenzoic acid 2-diethylaminoethyl ester | dicurin procaine | diethylaminoethyl p-aminobenzoate | herocaine | irocaine | isocain | isocaine | merethoxylline procaine | novocain | novocaine | p-aminobenzoic acid 2-diethylaminoethyl ester | pasconeural n | procain | procaina | procaine | procaine hcl | procaine hydrochloride | procaine merethoxylline | procainum | rocaine | sp01a | spinocaine | vitamin h3 | β-(diethylamino)ethyl 4-aminobenzoate | β-(diethylamino)ethyl p-aminobenzoate


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