Active Ingredient History

Lodoxamide is a mast-cell stabilizer for topical administration into the eye. This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. Lodoxamide inhibits the in vivo Type I immediate hypersensitivity reaction. In vitro, Lodoxamide stabilizes mast cells and prevents antigen-stimulated release of histamine. In addition, Lodoxamide prevents the release of other mast cell inflammatory mediators and inhibits eosinophil chemotaxis. Although Lodoxamide's precise mechanism of action is unknown, the drug has been reported to prevent calcium influx into mast cells upon antigen stimulation. Among side effects to Lodoxamide, the most frequently reported ocular adverse experiences were transient burning, stinging, or discomfort upon instillation. Nonocular events reported were headache and heat sensation, dizziness, somnolence, nausea, stomach discomfort, sneezing, dry nose, and rash.   NCATS

  • SMILES: OC(=O)C(=O)NC1=CC(=CC(NC(=O)C(O)=O)=C1Cl)C#N
  • Mol. Mass: 311.635
  • ALogP: 0.26
  • ChEMBL Molecules:
More Chemistry
2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxoacetic acid), diethyl ester | diethyl n,n'-(2-chloro-5-cyano-m-phenylene)dioxamate | lodoxamide | lodoxamide ethyl | n,n'-(2-chloro-5-cyano-m-phenylene)dioxamate | u 42585e | u-42,718


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