Active Ingredient History

  • Now
Diphenoxylate is an opioid drug used for the treatment of acute diarrhea. The drug is used in combination with atropine and marketed under names Lomotil and Diphenoxylate hydrochloride and atropine sulfate. Diphenoxylate is biotransformed in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood. The drug exerts its action by activating mu opioid receptors of intestinal mucosa.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( atropine, diphenoxylate - other names: colonai, di-atro, logen, lonox, lo-trol )
1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester | 2,2-diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile | 4-ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile | 4-piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride, mixt. with endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)benzeneacetate sulfate (2:1) (salt) | atropine sulfate - diphenoxylate hydrochloride | atropine sulfate-diphenoxylate hydrochloride drug combination | difenossilato | difenoxilato | diphenoxylate | diphenoxylate hcl | diphenoxylate hydrochloride | diphenoxylatum | ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate | ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate | lomotil | reasec


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