Active Ingredient History

  • Now
Decoglurant (INN) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.   Wikipedia

  • SMILES: Nc1ccc(cn1)C#Cc2cnn3c(cc(nc23)c4ccc(cc4)C(F)(F)F)C(F)(F)F
  • Mol. Mass: 447.34
  • ALogP: 4.81
  • ChEMBL Molecule:
More Chemistry
decoglurant | rg-1578 | ro4995819 | ro-4995819


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