Active Ingredient History

  • Now
Aztreonam is the first monocyclic beta-lactam antibiotic (monobactam) originally isolated from Chromobacterium violaceum. Aztreonam has a high affinity for the protein-binding protein 3 (PBP-3) of aerobic gram-negative bacteria. Most of these organisms are inhibited and killed at low concentrations of the drug. Aztreonam must be administered as an intravenous or intramuscular injection (AZACTAM®), or inhaled (CAYSTON®). Aztreonam for injection is indicated for the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract, lower respiratory tract, skin and skin-structure, intra-abdominal and gynecologic infections as well as for septicemia. Aztreonam for inhalation solution is indicated to improve respiratory symptoms in cystic fibrosis patients with Pseudomonas aeruginosa.   NCATS

  • SMILES: C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C2=CSC(N)=N2)C(=O)N1S(O)(=O)=O
  • Mol. Mass: 435.433
  • ALogP: -1.17
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$21.3390 - $57.1850
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-({[(1z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2s,3s)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acid | azactam | azonam | azthreonam | aztreon | aztreonam | aztréonam | aztreonam lysine | aztreonam lysine [usan] | aztreonamum | cayston | monobactam | nebactam | primbactam | so-26776 | sq-26776 | (z,)-2-((((2-amino-4-thiazolyl)(((2s,3s,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid


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