Active Ingredient History

  • Now
Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. The DNA damage leads to apoptosis of the affected cells. Chemically it is a derivative of nitrogen mustard and uracil.   NCATS

  • Mol. Mass: 252.098
  • ALogP: 0.35
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No
5-aminouracil mustard | 5-[bis(2-chloroethyl)amino]-2,4(1h,3h)-pyrimidinedione | 5-(di-2-chloroethyl)aminouracil | 5-[di(beta-chloroethyl)amino]uracil | 5-n,n-bis(2-chloroethyl)aminouracil | aminouracil mustard | chlorethaminacil | demethyldopan | desmethyldopan | u-8344 | uracil mustard | uracil nitrogen mustard | uramustin | uramustine


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