Active Ingredient History

  • Now
Loracarbef (KT3777) is carbacephem antibiotic structurally identical to cefaclor, except that the sulfur atom of position 1 of the cephem nucleus has been replaced by carbon. It showed good affinity for penicillin-binding proteins. At low concentrations (< 2 mg/L) in vitro, it inhibits Streptococcus pneumoniae, S. pyogenes, beta-haemolytic streptococci groups B, C and G. Proteus mirabilis and Moraxella catarrhalis, including beta-lactamase-producing strains. At therapeutic plasma concentrations it is also active in vitro against most strains of Staphylococcus aureus, S. saprophyticus, Escherichia coli and beta-lactamase-positive and -negative strains of Haemophilus influenzae. Loracarbef has been indicated in the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.   NCATS

  • SMILES: N[C@@H](C(=O)N[C@H]1[C@H]2CCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3
  • Mol. Mass: 349.77
  • ALogP: 0.71
  • ChEMBL Molecules:
More Chemistry
1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6r-(6alpha,7beta(r*)))- | anhydrous loracarbef | carbac | kt 3777 | kt-3777 | lilly brand of loracarbef | lilly brand of loracarbef monohydrate | lorabid | loracarbef | loracarbef, anhydrous | loracarbef hydrate | loracarbef monohydrate | loracarbefum | lorafem | lorax | loribid | ly163892 | ly 163892 | ly-163892 | monarch brand of loracarbef monohydrate | syntex brand of loracarbef monohydrate | zambon brand of loracarbef monohydrate


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