rebamipide Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.   Wikipedia

Chemistry

  • SMILES: OC(=O)C(CC1=CC(=O)Nc2ccccc12)NC(=O)c3ccc(Cl)cc3
  • InChIKey: ALLWOAVDORUJLA-UHFFFAOYSA-N
  • Mol. Mass: 370.79
  • ALogP: 2.61
  • ChEMBL Molecule:
    rebamipide  
More Chemistry

Pharmacology

Alternative names

2-(4-chlorobenzoylamino)-3-(2(1h)-quinolinon-4-yl)propionic acid | mucosta | opc 12759 | opc-12759 | proamipide | rebamidpide | rebamipide | rebamipide, (-)-isomer | rebamipide, (+)-isomer | repamipide | sa001 | sa-001

Organizations (53)

Research & Development (53)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (23)

Approved Indications (1)


 

Gastritis

Experimental Indications - Clinical Trial Phases 1-4 (23)


 

Anti-Inflammatory Agents (Phase 4)

Arthritis, Rheumatoid (Phase 4)

Colitis, Ulcerative (Phase 2)

Corneal Diseases (Phase 2)

Dry Eye Syndromes (Phase 4)

Dyspepsia (Phase 4)

Enteritis (Phase 4)

Gastritis (Phase 4)

Gastroesophageal Reflux (Phase 4)

Head and Neck Neoplasms (Phase 2)

Healthy Volunteers (Phase 1)

Hypercholesterolemia (Phase 3)

Intestinal Neoplasms (Phase 1)

Keratoconjunctivitis Sicca (Phase 3)

Musculoskeletal Diseases (Phase 4)

Osteoarthritis (Phase 4)

Pancreatitis (Phase 3)

Peptic Ulcer (Phase 2/Phase 3)

Sjogren's Syndrome (Phase 4)

Spondylitis, Ankylosing (Phase 4)

Stomach Diseases (Phase 4)

Stomach Ulcer (Phase 4)

Xerostomia (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 55
  • # of Trial Organizations: 53

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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