Active Ingredient History
Canagliflozin (INN, trade name Invokana or Sulisent) is a drug of the gliflozin class. It was developed by Mitsubishi Tanabe Pharma and is marketed under license by Janssen, a division of Johnson & Johnson. Canagliflozin is an antidiabetic drug used to improve glycemic control in people with type 2 diabetes. Sodium-glucose co-transporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Canagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, canagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose (RTG), and thereby increases urinary glucose excretion. In extensive clinical trials, canagliflozin produced a consistent dose-dependent reduction in HbA1c of 0.77% to 1.16% when administered as monotherapy, combination with metformin, combination with metformin and a sulfonylurea, combination with metformin and pioglitazone, and in combination with insulin from a baselines of 7.8% to 8.1%, in combination with metformin, or in combination with metformin and a sulfonylurea. When added to metformin, canagliflozin 100 mg was shown to be non-inferior to both sitagliptin 100 mg and glimepiride in reductions on HbA1c at one year, whilst canagliflozin 300 mg successfully demonstrated statistical superiority over both sitagliptin and glimiperide in HbA1c reductions. Secondary efficacy endpoint of superior body weight reduction and blood pressure reduction (versus sitagliptin and glimiperide)) were observed as well. Canagliflozin produces beneficial effects on HDL cholesterol whilst increasing LDL cholesterol to produce no change in total cholesterol. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Diabetes Mellitus, Type 2 (approved 2013)
Albuminuria (Phase 4)
Breast Neoplasms (Phase 2)
Cardiovascular Diseases (Phase 4)
Colorectal Neoplasms (Phase 1/Phase 2)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 2)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Nephropathies (Phase 3)
Endometrial Neoplasms (Phase 1/Phase 2)
Gout (Phase 4)
Head and Neck Neoplasms (Phase 1/Phase 2)
Healthy Volunteers (Phase 1)
Heart Failure (Phase 3)
Heart Failure, Systolic (Phase 4)
Hepatic Insufficiency (Phase 1)
Hypertension (Phase 4)
Hyperuricemia (Phase 4)
Lung Neoplasms (Phase 1/Phase 2)
Obesity (Phase 4)
Overweight (Phase 4)
Plasma Volume (Phase 1)
Polycystic Ovary Syndrome (Phase 1/Phase 2)
Renal Insufficiency (Phase 3)
Risk Factors (Phase 3)
Stroke (Phase 2)
Therapeutic Equivalency (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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