Active Ingredient History
Pregabalin, marketed under the brand name Lyrica among others. LYRICA is indicated for: Neuropathic pain associated with diabetic peripheral neuropathy (DPN) Postherpetic neuralgia (PHN); Adjunctive therapy for adult patients with partial onset seizures; Fibromyalgia; Neuropathic pain associated with spinal cord injury. It has been shown the clinical effects of pregabalin are likely due to direct and selective interactions with α(2)δ-1 and α(2)δ-2 subunits of voltage-gated calcium channels. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Diabetic Neuropathies (approved 2004)
Neuralgia, Postherpetic (approved 2004)
Abdominal Pain (Phase 4)
Acute Pain (Phase 4)
Alcoholism (Phase 4)
Analgesia (Phase 4)
Analgesics (Phase 4)
Analgesics, Opioid (Phase 4)
Anesthesia (Phase 4)
Anesthesia, General (Phase 4)
Anxiety (Phase 4)
Anxiety Disorders (Phase 4)
Arterial Occlusive Diseases (Phase 4)
Arthroplasty (Phase 1/Phase 2)
Arthroplasty, Replacement, Hip (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Back Pain (Phase 4)
Behavior, Addictive (Phase 2/Phase 3)
Bone Neoplasms (Phase 4)
Brain Neoplasms (Phase 2)
Breast Neoplasms (Phase 3)
Cannabis (Early Phase 1)
Catheters (Phase 2/Phase 3)
Cervix Uteri (Phase 4)
Cholecystectomy, Laparoscopic (Phase 4)
Chronic Disease (Phase 4)
Chronic Limb-Threatening Ischemia (Phase 4)
Chronic Pain (Phase 4)
Complex Regional Pain Syndromes (Phase 2)
Conscious Sedation (Phase 2)
Cough (Phase 1/Phase 2)
Delirium (Phase 3)
Dementia (Phase 3)
Dental Anxiety (Phase 2)
Depression (Phase 3)
Diabetes Mellitus (Phase 4)
Diabetic Neuropathies (Phase 4)
Drug Resistant Epilepsy (Phase 4)
Drugs, Investigational (Phase 2/Phase 3)
Dry Eye Syndromes (Phase 2/Phase 3)
Earache (Phase 2)
Epidermolysis Bullosa (Phase 3)
Epilepsies, Partial (Phase 4)
Epilepsy ()
Epilepsy, Complex Partial (Phase 4)
Epinephrine (Phase 4)
Essential Tremor (Phase 4)
Facial Pain (Phase 2)
Failed Back Surgery Syndrome (Phase 4)
Fibromyalgia ()
Fractures, Bone (Early Phase 1)
Gabapentin (Phase 4)
General Surgery (Phase 3)
Glioma (Phase 4)
Gulf War (Phase 2)
Headache (Phase 4)
Head and Neck Neoplasms (Phase 4)
Healthy Volunteers (Phase 4)
Hernia, Inguinal (Phase 3)
Herpes Zoster (Phase 4)
HIV Infections (Phase 4)
Hot Flashes (Phase 3)
Hyperalgesia (Phase 4)
Hysterectomy (Phase 3)
Intervertebral Disc Displacement (Phase 4)
Intubation (Phase 4)
Irritable Bowel Syndrome (Phase 4)
Ischemia (Phase 4)
Ischemic Stroke (Phase 3)
Kidney Calculi (Phase 2/Phase 3)
Kidney Diseases (Phase 1)
Laparoscopy (Phase 4)
Leiomyoma (Phase 4)
Liver Cirrhosis (Phase 3)
Liver Neoplasms (Phase 4)
Living Donors (Phase 4)
Low Back Pain (Phase 4)
Lymphoma (Phase 2)
Migraine Disorders (Phase 4)
Mucositis (Phase 2)
Multiple Sclerosis (Phase 3)
Muscle Cramp (Phase 3)
Narcotics (Phase 4)
Nausea (Phase 2)
Neoplasms (Phase 4)
Nephrolithiasis (Phase 3)
Nerve Degeneration (Phase 4)
Nerve Fibers (Phase 4)
Neuralgia ()
Neuralgia, Postherpetic (Phase 4)
Neurosurgical Procedures (Phase 2/Phase 3)
Obsessive-Compulsive Disorder (Phase 4)
Opioid-Related Disorders (Phase 4)
Orthopedics (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Knee (Phase 4)
Pain (Phase 4)
Pain, Intractable (Phase 4)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 4)
Pancreatitis, Chronic (Phase 2/Phase 3)
Peripheral Nerve Injuries (Phase 3)
Peripheral Nervous System Diseases (Phase 3)
Phantom Limb (Phase 3)
Pharmacokinetics (Phase 2)
Polyneuropathies (Phase 4)
Polyradiculoneuropathy (Phase 4)
Post-Dural Puncture Headache (Phase 4)
Postoperative Complications (Phase 4)
Pregabalin (Phase 2/Phase 3)
Pregnancy (Phase 1)
Prostatitis (Phase 3)
Pruritus (Phase 4)
Psychophysiologic Disorders (Phase 3)
Radiculopathy (Phase 4)
Refractive Errors (Phase 1)
Reperfusion Injury (Phase 4)
Restless Legs Syndrome (Phase 4)
Schizophrenia (Phase 4)
Scoliosis (Phase 4)
Seizures ()
Sleep Deprivation (Phase 3)
Sleep Wake Disorders (Phase 3)
Sphenopalatine Ganglion Block (Phase 4)
Spinal Cord Diseases (Phase 3)
Spinal Cord Injuries (Phase 4)
Spinal Cord Neoplasms (Phase 2/Phase 3)
Spinal Diseases (Phase 4)
Spinal Fusion (Phase 3)
Spinal Stenosis (Phase 4)
Spondylolisthesis (Phase 4)
Spondylosis (Phase 4)
Stress Disorders, Post-Traumatic (Phase 3)
Substance Abuse, Oral (Phase 4)
Substance-Related Disorders (Phase 4)
Tissue Adhesions (Phase 4)
Tobacco Use Disorder (Early Phase 1)
Urinary Bladder, Overactive (Phase 2)
Urolithiasis (Phase 3)
Urologic Diseases (Phase 3)
Uterine Artery Embolization (Phase 4)
Visceral Pain (Phase 4)
Vulvar Vestibulitis (Phase 2)
Vulvodynia (Phase 2)
Wounds and Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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