API | telenzepine

telenzepine Report issue

Small molecule Experimental

AACT ChEMBL MeSH PubChem

Active Ingredient History

NOW

Telenzepine is a thienobenzodiazepine acting as selective M1 antimuscarinic. It is used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis. In neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active than the (–)-isomer at muscarinic receptors in the rat cerebral cortex. ^Wikipedia

Chemistry

SMILES: CN1CCN(CC(=O)N2c3ccccc3NC(=O)c4csc(C)c24)CC1
InChIKey: VSWPGAIWKHPTKX-UHFFFAOYSA-N
Mol. Mass: 370.48
ALogP: 2.53 Partition coefficient
ChEMBL Molecule:
telenzepine

More Chemistry

Pharmacology

Mechanisms of Action: Missing data
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

4,9-dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl)-10h-thieno(3,4-b)(1,5)benzodiazepin-10-one | telenzepine

Organizations (2)

Research & Development (2)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (1)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (1)

Obesity (Phase 1)

Overview

Highest Phase: Phase 1
# of Trials: 1
# of Trial Organizations: 2

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

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