Active Ingredient History

  • Now
Panthenol (pantothenol) is an alcohol form of the B5 vitamin pantothenic acid. It easily penetrates the skin retaining water and is a humectant, emollient and moisturizer. Panthenol mitigates signs of inflammation and stimulates epithelization. Panthenol comes in two enantiomers, D and L. Only D-panthenol (dexpanthenol) is biologically active, however both forms have moisturizing properties. Because of the ability to attract and hold moisture panthenol is used in skincare products as a humectant. It also has a role as provitamin (called pro-vitamin B5) and is used as a vitamin supplement in complex ( M.V.I. ADULT injection, Hospira Worldwide, Inc.) and alone, and as a cholinergic drug. Panthenol is a highly viscous transparent liquid at room temperature, but salts of pantothenic acid (sodium pantothenate) are powders (typically white). It is soluble in water, alcohol, propylene glycol, ether and chloroform, and slightly soluble in glycerin. Panthenol mixes readily with many different types of ingredients, making it a versatile ingredient to be used in formulas because it improves skin’s barrier function and maintains the proliferation of fibroblasts. In organisms it is quickly oxidized to pantothenate (pantothenic acid). Defficiency of Vitamin B5 results in many dermatological disorder. Due to the fact that only D-Panthenol is converted to Vitamin B5 and not L-Panthenol, the racemic mixture of D- and L- panthenol (DL-panthenol) has only half of the physiological activity of the D-Panthenol. These include stimulation of epithelisation, wound healing effect and anti-infl ammatory effect. Panthenol is FDA approved for cosmetic use and comes either in D form, or as a racemic mixture. It is also in the FDA list of over-the-counter drug products that are not generally recognized as safe and effective or are misbranded: as "Insect Bite and Sting Drug Products" and "Poison Ivy, Poison Oak, and Poison Sumac Drug Products".   NCATS

  • Mol. Mass: 205.2515
  • ALogP: -1.14
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No
2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutanamide | (+)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutyramide | (2r)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutanamide | bepanthen | bepanthene | bepantol | butanamide, 2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-, (+--)- | corneregel | cozyme | d-(+)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutyramide | dexpantenol | dexpanthenol | dexpanthenol heumann | dl-panthenol | d-panthenol | d(+)-panthenol | d-panthenol 50 | d-pantothenol | d-pantothenyl alcohol | d(+)-pantothenyl alcohol | ilopan | marolderm | motilyn | nasenspray ratiopharm panthenol | nasicur | n-pantoyl-propanolamine | otriven dexpanthenol | panadon | pan-ophtal | pan rhinol | panthenol | (+)-panthenol | panthenol braun | panthenol jenapharm | panthenol law | panthenol lichtenstein | panthenol-ratiopharm | panthenol von ct | panthoderm | panthogenat | pantol | pantothenol | pantothenyl alcohol | provitamin b | (r)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutanamide | repa-ophtal | rhinoclir | royal jelly | sinecort | siozwo sana | synapan | thenalton | ucee d | urupan | wund- und heilsalbe law | zentinic


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