Active Ingredient History
Morphine is one of the most important and widely used opioid for the treatment of chronic and acute pain: the very wide interindividual variability in the patients’ response to the drug may have genetic derivations. Sulphate salt of morphine sold under the many brand names, one of them, DURAMORPH, which is indicated for the management of pain severe enough to require use of an opioid analgesic by intravenous administration, and for which alternative treatments are not expected to be adequate. In addition for the epidural or intrathecal management of pain without attendant loss of motor, sensory, or sympathetic function. Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of morphine is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with morphine. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug. Morphine has a high potential for addiction and abuse. Common side effects include drowsiness, vomiting, and constipation. Caution is advised when used during pregnancy or breast-feeding, as morphine will affect the baby. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdomen, Acute (Phase 4)
Abdominal Neoplasms (Phase 4)
Abdominal Pain (Phase 4)
Ablation Techniques (Phase 4)
Abortion, Induced (Phase 3)
Abscess (Phase 3)
Acute Coronary Syndrome (Phase 4)
Acute Pain (Phase 4)
Aged (Phase 4)
Allergy and Immunology (Phase 4)
Ambulances (Phase 3)
Amputation (Phase 2)
Analgesia (Phase 4)
Analgesia, Epidural (Phase 4)
Analgesia, Obstetrical (Phase 4)
Analgesia, Patient-Controlled (Phase 4)
Analgesics (Phase 4)
Analgesics, Opioid (Phase 4)
Anemia, Sickle Cell (Phase 4)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 2)
Anesthesia, Caudal (Phase 4)
Anesthesia, Epidural (Phase 4)
Anesthesia, Local (Phase 4)
Anesthesia Recovery Period (Phase 4)
Anesthesia, Spinal (Phase 4)
Anesthetics, Local (Phase 4)
Angina, Unstable (Phase 4)
Ankle Fractures (Phase 4)
Anxiety (Phase 4)
Aorta (Phase 4)
Aortic Aneurysm, Abdominal (Phase 4)
Appendicitis (Phase 4)
Arterial Occlusive Diseases (Phase 3)
Arthropathy, Neurogenic (Phase 4)
Arthroplasty, Replacement, Hip (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Autografts (Phase 4)
Back Pain (Phase 4)
Behavior, Addictive (Phase 2)
Blood Coagulation (Phase 2)
Brain Injuries (Phase 2)
Brain Neoplasms (Phase 4)
Breakthrough Pain (Phase 4)
Breast Neoplasms (Phase 4)
Bunion (Phase 3)
Cancer Pain (Phase 4)
Cannabidiol (Phase 1)
Cardiopulmonary Bypass (Phase 4)
Cardiovascular Diseases (Phase 4)
Central Nervous System Depressants (Phase 4)
Cesarean Section (Phase 4)
Child (Phase 4)
Chlorzoxazone (Phase 4)
Chronic Disease (Phase 4)
Chronic Pain (Phase 4)
Colonic Neoplasms (Phase 4)
Colorectal Neoplasms (Phase 4)
Colorectal Surgery (Phase 4)
Colostomy (Phase 4)
Communication (Phase 2)
Complex Regional Pain Syndromes (Phase 4)
Consciousness Disorders (Phase 2)
Conscious Sedation (Phase 4)
Constipation (Phase 4)
Coronary Artery Disease (Phase 4)
Craniocerebral Trauma (Phase 1/Phase 2)
Critical Illness (Phase 2/Phase 3)
Cystitis, Interstitial (Phase 4)
Delirium (Phase 4)
Delivery, Obstetric (Phase 4)
Dementia (Phase 2/Phase 3)
Depression (Phase 4)
Depression, Postpartum (Phase 4)
Dexmedetomidine (Phase 4)
Diabetes Mellitus (Phase 3)
Diabetic Neuropathies (Phase 2)
Diverticulitis (Phase 1/Phase 2)
Diverticulitis, Colonic (Phase 4)
Drug Interactions (Phase 4)
Drugs, Investigational (Phase 3)
Dyspnea (Phase 4)
Dyspnea, Paroxysmal (Phase 2)
Edema (Phase 4)
Emergencies (Phase 3)
Emergency Medicine (Phase 4)
End Stage Liver Disease (Phase 4)
Epidermal Cells (Phase 4)
Fascia (Phase 4)
Fatty Liver (Phase 1)
Femoracetabular Impingement (Phase 4)
Femoral Fractures (Phase 4)
Femoral Neck Fractures (Phase 4)
Fentanyl (Phase 3)
Flail Chest (Phase 2/Phase 3)
Flank Pain (Phase 4)
Fractures, Bone (Phase 4)
Funnel Chest (Phase 4)
Gallstones (Phase 4)
Gastric Emptying (Phase 1)
Gastrostomy (Phase 4)
General Surgery (Phase 4)
Genetic Diseases, Inborn (Phase 2)
Gynecology (Phase 4)
Hallucinations (Phase 3)
Hallux Valgus (Phase 4)
Head and Neck Neoplasms (Phase 4)
Head Injuries, Closed (Phase 2)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 4)
Hemoglobins (Phase 2)
Hernia, Inguinal (Phase 4)
Heroin Dependence (Phase 2)
Herpes Zoster (Phase 3)
Hip Fractures (Phase 4)
Humans (Phase 4)
Hyperalgesia (Phase 4)
Hypertension (Phase 2/Phase 3)
Hypotension (Phase 4)
Hypoxia-Ischemia, Brain (Phase 2)
Hysterectomy (Phase 4)
Hysterectomy, Vaginal (Phase 4)
Idiopathic Pulmonary Fibrosis (Phase 3)
Ileus (Phase 4)
Immune System Diseases (Phase 4)
Infant, Newborn (Phase 3)
Infant, Premature (Phase 2)
Inflammatory Bowel Diseases (Phase 1/Phase 2)
Infratentorial Neoplasms (Phase 2)
Infusion Pumps (Phase 4)
Injections, Spinal (Phase 4)
Intervertebral Disc Degeneration (Phase 4)
Intervertebral Disc Displacement (Phase 4)
Intestinal Diseases (Phase 4)
Intestinal Neoplasms (Phase 3)
Intestinal Pseudo-Obstruction (Phase 4)
Ketamine (Early Phase 1)
Kidney Calculi (Phase 3)
Kidney Failure, Chronic (Phase 4)
Knee Injuries (Phase 4)
Labor Pain (Phase 4)
Laparoscopy (Phase 4)
Leg Injuries (Phase 4)
Leiomyoma (Phase 2)
Leukemia (Phase 3)
Leukemia, Myeloid, Acute (Phase 3)
Liver Diseases (Phase 4)
Low Back Pain (Phase 4)
Lumbar Vertebrae (Phase 3)
Lung Diseases (Phase 4)
Lung Diseases, Interstitial (Phase 4)
Lung Neoplasms (Phase 4)
Lymphoma (Phase 3)
Mastectomy (Phase 4)
Methadone (Phase 4)
Morphine (Phase 4)
Mucositis (Phase 4)
Multiple Myeloma (Phase 3)
Musculoskeletal Pain (Phase 4)
Myelodysplastic Syndromes (Phase 3)
Myeloproliferative Disorders (Phase 3)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 4)
Myoma (Phase 4)
Narcotic-Related Disorders (Phase 4)
Narcotics (Phase 4)
Nasopharyngeal Carcinoma (Phase 4)
Nausea (Phase 4)
Neonatal Abstinence Syndrome (Phase 4)
Neoplasm Metastasis (Phase 3)
Neoplasm, Residual (Phase 4)
Neoplasms ()
Neoplasms, Adnexal and Skin Appendage (Phase 2)
Neoplastic Cells, Circulating (Phase 4)
Nephrectomy (Phase 2)
Nerve Block (Phase 4)
Neuralgia (Phase 4)
Obesity (Phase 4)
Obesity, Morbid (Phase 4)
Only Child (Phase 3)
Opiate Overdose (Phase 3)
Opiate Substitution Treatment (Phase 3)
Opioid-Related Disorders (Phase 4)
Organic Cation Transporter 1 (Phase 1)
Orthopedic Procedures (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Hip (Phase 4)
Osteoarthritis, Knee (Phase 4)
Otitis Media (Phase 4)
Pain ()
Pain, Intractable (Phase 3)
Pain Management (Phase 4)
Pain Measurement (Phase 3)
Pain, Postoperative (Phase 4)
Pain, Referred (Phase 2)
Patient Satisfaction (Phase 4)
Perineum (Phase 1)
Persistent Vegetative State (Phase 2)
Pharmacokinetics (Phase 4)
Pharyngeal Diseases (Phase 4)
Post-Dural Puncture Headache (Phase 4)
Postoperative Cognitive Complications (Phase 2)
Postoperative Complications (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Postoperative Period (Phase 4)
Precancerous Conditions (Phase 3)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 3)
Pregnant Women (Phase 3)
Prostatectomy (Phase 4)
Prostatic Neoplasms (Phase 3)
Pruritus (Phase 4)
Pulmonary Arterial Hypertension (Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Quality of Life (Phase 4)
Radiculopathy (Phase 2)
Recovery of Function (Phase 4)
Rectal Neoplasms (Phase 4)
Renal Colic (Phase 4)
Respiratory Insufficiency (Phase 4)
Restless Legs Syndrome (Phase 1)
Rheumatic Diseases (Phase 1/Phase 2)
Rib Fractures (Phase 4)
Rotator Cuff Injuries (Phase 2)
Safety (Phase 4)
Sciatica (Phase 4)
Scoliosis (Phase 4)
Sepsis (Phase 4)
Shoulder (Phase 4)
Shoulder Pain (Phase 3)
Skin Transplantation (Phase 3)
Sleep Apnea, Obstructive (Phase 3)
Sleep Apnea Syndromes (Phase 4)
Sleep Disorders, Intrinsic (Phase 3)
Sleep Wake Disorders (Phase 4)
Sphincter of Oddi Dysfunction (Phase 4)
Spinal Cord Injuries (Phase 2)
Spinal Fusion (Phase 4)
Spinal Stenosis (Phase 4)
Spondylolisthesis (Phase 4)
ST Elevation Myocardial Infarction (Phase 4)
Stomach Neoplasms (Phase 4)
Stomatitis (Phase 2/Phase 3)
Subarachnoid Hemorrhage (Phase 1/Phase 2)
Substance Abuse, Oral (Phase 2)
Substance-Related Disorders (Phase 4)
Sufentanil (Phase 4)
Supratentorial Neoplasms (Phase 4)
Swallows (Phase 4)
Tendon Injuries (Phase 4)
Terminally Ill (Phase 4)
Thoracic Injuries (Phase 2)
Thoracic Surgery, Video-Assisted (Phase 4)
Thorax (Phase 3)
Tonsillectomy (Phase 4)
Tonsillitis (Phase 4)
Tooth (Phase 2)
Ultrasonography (Phase 4)
Urinary Bladder, Neurogenic (Phase 4)
Urinary Bladder, Overactive (Phase 4)
Urinary Calculi (Phase 4)
Urinary Incontinence, Urge (Phase 4)
Urolithiasis (Phase 4)
Uterus (Phase 2)
Vasoplegia (Early Phase 1)
Ventricular Dysfunction, Right (Phase 4)
Vomiting (Phase 4)
Wounds and Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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