Active Ingredient History

  • Now
Methylergometrine (other names include methylergonovine, methylergobasin, methergine, and D-lysergic acid 1-butanolamide) is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result. Methylergometrine acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions through binding and the resultant antagonism of the dopamine D1 receptor. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss. Methylergometrine is used for the prevention and control of excessive bleeding following vaginal childbirth.   NCATS

More Chemistry

Drug Pricing (per unit)

United States

$18.1407 - $18.1408
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

9,10-didehydro-n-[1-(hydroxymethyl)-propyl]-d-lysergamide | d-lysergic acid 1-butanolamide | ergotyl | methergen | methergine | methylergobasin | methylergobasine | methylergobrevin | methylergometrin | methylergometrine | méthylergométrine | methylergometrine maleate | methylergometrinum | methylergonovine | methylergonovine maleate | methylergonovinium bimaleate | metilergometrina | partergin


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue