Active Ingredient History
Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin. Tranexamic acid is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of plasmin, i.e., actions similar to aminocaproic acid. Tranexamic acid is about 10 times more potent in vitro than aminocaproic acid. Tranexamic acid binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds. Tranexamic acid in a concentration of 1 mg per mL does not aggregate platelets in vitro. In patients with hereditary angioedema, inhibition of the formation and activity of plasmin by tranexamic acid may prevent attacks of angioedema by decreasing plasmin-induced activation of the first complement protein (C1). Tranexamic acid is used for use in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction. It can also be used for excessive bleeding in menstruation, surgery, or trauma cases. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominoplasty (Phase 4)
Adenoidectomy (Phase 4)
Analgesics, Opioid (Phase 4)
Anemia (Phase 4)
Anesthesia (Phase 4)
Angioedemas, Hereditary (Phase 3)
Anterior Cruciate Ligament Injuries (Phase 4)
Antifibrinolytic Agents (Phase 4)
Aortic Aneurysm, Abdominal (Phase 3)
Aortic Valve Disease (Phase 3)
Arteriovenous Fistula (Phase 4)
Arthritis (Phase 4)
Arthropathy, Neurogenic (Phase 4)
Arthroplasty (Phase 4)
Arthroplasty, Replacement, Hip (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Arthroscopy (Phase 3)
Astrocytoma (Phase 3)
Atherosclerosis (Phase 3)
Back Pain (Early Phase 1)
Biliary Tract Surgical Procedures (Phase 4)
Blood Circulation (Phase 4)
Blood Coagulation (Phase 3)
Blood Loss, Surgical (Phase 4)
Blood Transfusion (Phase 4)
Bone Neoplasms (Phase 3)
Brain Injuries (Phase 3)
Brain Injuries, Traumatic (Phase 3)
Brain Neoplasms (Phase 3)
Breast Neoplasms (Phase 4)
Bronchiectasis (Phase 3)
Bronchoscopy (Phase 2)
Bunion (Phase 4)
Burns (Phase 4)
Carcinoma (Phase 3)
Cardiac Surgical Procedures (Phase 4)
Cardiopulmonary Bypass (Phase 4)
Cerebral Hemorrhage (Phase 2/Phase 3)
Cerebral Intraventricular Hemorrhage (Phase 1)
Cesarean Section (Phase 4)
Chronic Urticaria (Phase 4)
Cleft Palate (Phase 4)
Colectomy (Phase 4)
Colonic Neoplasms (Phase 2/Phase 3)
Colorectal Surgery (Phase 4)
Contusions (Phase 4)
Coronary Artery Disease (Phase 4)
COVID-19 (Phase 3)
Craniosynostoses (Phase 4)
Critical Illness (Phase 2)
Cross Infection (Phase 4)
Delivery, Obstetric (Phase 2)
Digestive System Diseases (Phase 4)
Drug Evaluation (Phase 1)
Dupuytren Contracture (Phase 4)
Edema (Phase 4)
Emergency Service, Hospital (Phase 4)
Epistaxis (Phase 4)
Esophagectomy (Phase 4)
Eye Diseases, Hereditary (Phase 4)
Facial Injuries (Phase 4)
Factor VIII (Phase 4)
Femoral Fractures (Phase 4)
Femoral Neck Fractures (Phase 4)
Fibrosis (Phase 4)
Fractures, Bone (Phase 4)
Gastrectomy (Phase 4)
Gastrointestinal Hemorrhage (Phase 4)
General Surgery (Phase 4)
Glioma (Phase 3)
Gynecologic Surgical Procedures (Phase 4)
Hand Injuries (Phase 4)
Head and Neck Neoplasms (Phase 3)
Healthy Volunteers (Phase 1)
Heart Defects, Congenital (Phase 4)
Hematologic Neoplasms (Phase 3)
Hematoma (Phase 4)
Hematoma, Subdural (Phase 4)
Hematoma, Subdural, Chronic (Phase 3)
Hematopoietic Stem Cell Transplantation (Phase 3)
Hematuria (Phase 1/Phase 2)
Hemoptysis (Phase 3)
Hemorrhage ()
Hemostatic Disorders (Phase 1/Phase 2)
Hip Fractures (Phase 4)
Hip Injuries (Phase 4)
Homeostasis (Phase 4)
Hypotension (Phase 2)
Hysterectomy (Phase 4)
Ileus (Phase 2)
Inflammation (Phase 3)
Intervertebral Disc Degeneration (Phase 2)
Intestinal Neoplasms (Phase 4)
Intestinal Polyps (Phase 4)
Intraoperative Complications (Phase 2/Phase 3)
Knee Prosthesis (Early Phase 1)
Labor, Obstetric (Phase 3)
Leiomyoma (Phase 4)
Limb Salvage (Phase 3)
Liver Neoplasms (Phase 2/Phase 3)
Lymphoma (Phase 2)
Melanosis (Phase 4)
Membranes (Phase 4)
Meningioma (Phase 4)
Menorrhagia ()
Metrorrhagia (Phase 3)
Misoprostol (Phase 3)
Multiple Trauma (Phase 1/Phase 2)
Myocardial Infarction (Phase 4)
Myoma (Phase 3)
Nasal Obstruction (Phase 4)
Nasal Polyps (Phase 3)
Nasal Septal Perforation (Phase 4)
Neoplasms (Phase 4)
Nephrolithiasis (Phase 4)
Nurse's Role (Phase 1/Phase 2)
Obstetrics (Phase 3)
Orthognathic Surgery (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Hip (Phase 4)
Osteoarthritis, Knee (Phase 4)
Osteosarcoma (Phase 3)
Osteotomy (Phase 4)
Ovarian Neoplasms (Phase 4)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 2/Phase 3)
Pancreaticoduodenectomy (Phase 4)
Paranasal Sinus Diseases (Phase 3)
Patient Satisfaction (Phase 1/Phase 2)
Pelvic Organ Prolapse (Phase 3)
Pelvis (Phase 1)
Pharmacokinetics (Phase 3)
Pharmacology (Phase 4)
Physician-Nurse Relations (Phase 1/Phase 2)
Pituitary Neoplasms (Phase 2)
Placenta Accreta (Phase 4)
Placenta Previa (Phase 3)
Postoperative Complications (Phase 4)
Postoperative Hemorrhage (Phase 4)
Postpartum Hemorrhage (Phase 4)
Pregnancy Complications (Phase 4)
Pregnancy, High-Risk (Phase 2)
Prostatectomy (Phase 4)
Prostatic Neoplasms (Phase 1/Phase 2)
Pulmonary Embolism (Phase 4)
Retrognathia (Phase 3)
Rotator Cuff Injuries (Phase 4)
Sarcoma (Phase 4)
Sarcoma, Ewing (Phase 3)
Scoliosis (Phase 4)
Seizures (Phase 4)
Sepsis (Phase 3)
Seroma (Phase 4)
Shock (Phase 2)
Shock, Hemorrhagic (Phase 3)
Shock, Septic (Phase 3)
Shoulder Impingement Syndrome (Phase 4)
Shoulder Injuries (Phase 4)
Sinusitis (Phase 4)
Skin Neoplasms (Early Phase 1)
Spinal Diseases (Phase 3)
Spinal Fusion (Phase 4)
Spinal Injuries (Phase 2/Phase 3)
Spinal Stenosis (Phase 4)
Staghorn Calculi (Phase 4)
Stomach Neoplasms (Phase 2/Phase 3)
Stroke (Phase 4)
Subarachnoid Hemorrhage (Phase 2/Phase 3)
Surgical Procedures, Operative (Phase 2)
Surgical Wound (Phase 2)
Telangiectasia, Hereditary Hemorrhagic (Phase 3)
Thoracic Surgery (Phase 4)
Thrombocytopenia (Phase 3)
Thromboembolism (Phase 4)
Thrombosis (Phase 3)
Tissue Adhesions (Phase 2)
Tonsillectomy (Phase 4)
Tooth Extraction (Phase 4)
Tranexamic Acid (Phase 4)
Traumatology (Phase 3)
Urinary Bladder Neoplasms (Phase 2/Phase 3)
Urinary Retention (Phase 1/Phase 2)
Urologic Diseases (Phase 1/Phase 2)
Uterine Diseases (Phase 3)
Uterine Hemorrhage (Phase 4)
Uterine Inertia (Phase 4)
Uterine Myomectomy (Phase 4)
Venous Thromboembolism (Phase 4)
Venous Thrombosis (Phase 4)
von Willebrand Diseases (Phase 3)
Wound Infection (Phase 4)
Wounds and Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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