Active Ingredient History

  • Now
Bumetanide is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome. It blocks the reabsorption of sodium and fluid from the kidney's tubules. The most frequent clinical adverse reactions considered probably or possibly related to bumetanide are muscle cramps (seen in 1.1% of treated patients), dizziness (1.1%), hypotension (0.8%), headache (0.6%), nausea (0.6%) and encephalopathy (in patients with preexisting liver disease) (0.6%). One or more of these adverse reactions have been reported in approximately 4.1% of patients treated with Bumex (bumetanide). Lithium should generally not be given with diuretics (such as Bumex (bumetanide)) because they reduce its renal clearance and add a high risk of lithium toxicity. Bumex (bumetanide) may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.   NCATS

  • SMILES: CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)S(N)(=O)=O
  • Mol. Mass: 364.416
  • ALogP: 3.04
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0640 - $2.4090
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid | 3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid | 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid | 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid | betinex | bufenox | bumetanida | bumetanide | bumetanidum | bumethanide | bumex | burinex | lixil | ro-106338


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