Active Ingredient History

  • Now
Methadone, sold under the brand names Dolophine among others, is an synthetic opioid that is used as the hydrochloride to treat pain and as maintenance therapy or to help with detoxification in people with opioid dependence. Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine. Some data also indicate that methadone acts as an antagonist at the NMDA-receptor. The contribution of NMDA receptor antagonism to methadone’s efficacy is unknown. Most common adverse reactions are: lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. Avoid use mixed agonist/antagonist and partial agonist opioid analgesics with DOLOPHINE because they may reduce analgesic effect of DOLOPHINE or precipitate withdrawal symptoms.   NCATS

  • SMILES: CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2
  • Mol. Mass: 309.45
  • ALogP: 4.29
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0235 - $11.5190


$0.2070 - $25.7400
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

6-dimethylamino-4,4-diphenyl-3-heptanone | amidone | dl-methadone | d-methadone | dolophine | dolophine hcl | eptadone | heptadon | martindale | metadone | methadone | (+-)-methadone | (+/-)-methadone | (±)-methadone | methadone hcl | methadone hydrochloride | methadone hydrochloride intensol | methadon hcl | methadonium chloride | methadonum | methadose | metharose | methex | phy | physeptone | pinadone | symoron | synastone | westadone


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