Active Ingredient History

  • Now
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Zidovudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5′-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase α and γ. Zidovudine is used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections. Zidovudine is marketed as Retrovir.   NCATS

  • SMILES: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
  • Mol. Mass: 267.2413
  • ALogP: -0.2
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: Yes

Drug Pricing (per unit)

United States

$0.1833 - $28.7500


$1.2939 - $28.2674
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

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( lamivudine (epivir), nevirapine (viramune), zidovudine (retrovir) - other names: lamivudine/nevirapine/zidovudine tablets, lamivudine/zidovudine 150 mg/300 mg tablets co-packaged with nevirapine 200 mg tablets, lamivudine, zidovudine tabs 150mg/300mg co-packaged with nevirapine tabs 200mg )
( abacavir (ziagen), lamivudine (epivir), zidovudine (retrovir) - other name: abacavir sulfate; lamivudine; zidovudine )
abacavir (as sulfate) / lamivudine / zidovudine | azidothimidine | azidothymidine | azitidin | azt | bwa509u | bw-a509u | bw-a-509u | combivir | compound s | lamivudine / zidovudine | lamivudine / zidovudine / abacavir sulfate | lamivudine, zidovudine drug combination | retrovir | zdv | zidovudin | zidovudine | zidovudinum


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