Active Ingredient History
Upadacitinib (ABT-494) is a Janus kinase 1 (JAK1) inhibitor currently being developed by AbbVie for the treatment of rheumatoid arthritis (RA), Crohn’s disease, ulcerative colitis, atopic dermatitis, and psoriatic arthritis. It is also being investigated as a potential treatment for people with active ankylosing spondylitis (AS). Currently, upadacitinib is being evaluatedin six global phase III studies in RA and twophase III studies in psoriatic arthritis (PsA), inaddition to phase II studies in Crohn’s disease and atopicdermatitis and a combined phase II/III study inulcerative colitis. Upadacitinib is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Colitis, Ulcerative (approved 2019)
Arthritis, Juvenile (Phase 1)
Arthritis, Psoriatic (Phase 4)
Arthritis, Rheumatoid (Phase 4)
Axial Spondyloarthritis (Phase 3)
Biomarkers (Phase 3)
Carcinoma, Giant Cell (Phase 3)
Colitis, Ulcerative (Phase 3)
Crohn Disease (Phase 3)
Dermatitis, Atopic (Phase 3)
Hidradenitis Suppurativa (Phase 2)
Janus Kinase Inhibitors (Phase 3)
Lupus Erythematosus, Systemic (Phase 2)
Spondylarthritis (Phase 4)
Spondylitis, Ankylosing (Phase 2)
Takayasu Arteritis (Phase 3)
Ultrasonography (Phase 3)
Vitiligo (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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