The Clinical Drug Experience Knowledgebase ( CDEK ) is a platform intended to explore every active pharmaceutical ingredient (API) with evidence of clinical testing. CDEK aggregates metadata surrounding APIs such as clinical trial information, clinical indications, organizations responsible for development, mechanism of action, etc. The intended use of the CDEK platform reaches far across the biopharmaceutical enterprise. CDEK supports research fields such as drug discovery, chemo and bioinformatics, clinical and translational research, regulatory science, etc. Industry applications aided by CDEK include competitive intelligence, business development, identifying trends within the drug development industry, prioritizing drug development pipelines, etc. The platform is intended to serve a wide audience with a focus on drugs that have made it to clinical stage development.
The Center for Research Innovation in Biotechnology (CRIB) is dedicated to providing transparent information and analyses of drug discovery and development. Founded in 2014 at Washington University in St Louis, CRIB first analyzed FDA-approved medicines and later expanded to include other FDA-approved biomedical products, including vaccines and biologicals. CRIB investigators are also deepening our knowledge of the scientific, medical and commercial evolution of FDA-approved products.
Dr. Kinch is Executive Dean of Science at Long Island University and helps lead translation activities as Vice President for Innovation. In the course of his career, he has founded and led drug discovery enterprises in both industry and academia, including founding oncology at MedImmune, Inc. and founding the Center for Molecular Discovery at Yale University and the Center for Drug Discovery at Washington University in St Louis.
Tyler is a software developer with a background in web and database development. He is a Computer Science graduate of Michigan Technological University (Houghton, Mich.). His interests include the gathering and presentation of large datasets and GIS.
He is the lead database & application developer for the Center for Research Innovation and Biotechnology at Long Island University, and current architect of the CDEK platform. Outside work, Tyler enjoys gardening, hiking, and community service.
Zachary is a web application developer with a background in Full stack web applications and experimental web architectures. He has years of experience working on cutting edge web platforms and solving complex programming demands. His main interests are working with open source web based technologies.
He is the frontend developer for the Center for Research Innovation and Biotechnology at Long Island University, on the CDEK platform. In his free time he tinkers with research papers, 3d printing, and archery.
Inclusion criteria from each data source are as follows:
experimentalfrom the "All" DRUG GROUP release v5.0.7.
max_phasegreater than 0 from the ChEMBLdb release v23.
We are in the process of rolling out a data ingestion pipeline which will periodically query the databases mentioned above for any data not currently reflected in CDEK. Once released, this pipeline ensures CDEK is up to date with the most current API data available online.
Portions of the CDEK database have been exported for public consumption, and are available through a PostgreSQL data dump file.
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